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Two doses

The reality of a severe allergic reaction is that you must start treatment immediately.

In a study of 105 patients, 35% of people with severe allergic reactions required a second dose of epinephrine to reverse their symptoms. It is important that the symptoms subside significantly within the first ten minutes of the injection. If they don t you have to be prepared with a back-up dose. That s why Twinject comes with two doses.

After the first injection, prepare the second dose and get emergency medical help right away. If symptoms have not improved approximately 10 minutes after the first injection, inject the second dose. World Health Organization (WHO) and Anaphylaxis Canada recommend that you always have a second dose available, or one dose for every 10 to 20 minutes of travel time to a medical emergency facility.

More than 2 sequential doses of epinephrine should only be administered under direct medical supervision.

Biphasic anaphylactic reactions.

Some people have what is called a biphasic reaction that means that symptoms, once over, will actually return. This type of reaction occurs in 20% of cases. Unfortunately there are no markers or signs that allow your doctor to predict if you are susceptible to a biphasic reaction. That means carrying a back-up dose is vitally important. Usually the symptoms subside and then reoccur one to 8 hours following the initial reaction but can reoccur up to 38 hours later.